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Neurodegeneration Research Wiki


This Wiki site is maintained by the Department of Neuroscience, Institute of Psychiatry, King's College London. Its aim is to provide information on neurodegenerative diseases that is useful to to carers, students and researchers.


Neurodegeneration is the name given to the processes that lead to the death of cells in the brain and spinal cord. It contrasts with:

(i) necrotic cell death. This is caused by an acute injury, such as a penetrating wound, or by ischaemia, that is a reduction in the supply of oxygen to the brain because of stroke or heart attack.

and with:

(ii) apoptotic cell death is a normal developmental process. It is the planned or programmed death of unwanted cells.

One of the consistent feature of the neurodegenerative diseases is the formation of proteinaceous aggregates or inclusions. These may be found either outside or inside the dead or dying cells and are thought to be caused by abnormal interactions between proteins. Examples of extracellular aggregates are amyloid plaques in Alzheimers disease and aggregates of prion protein in bovine spongiform encephalopathy, or mad-cow disease one of a number of transmissible spongiform encephalopathies. Examples of intracellular inclusions are the neurofibrillary tangles in Alzheimer's disease and Progressive Supranuclear Palsy (PSP), Lewy bodies in Parkinsons disease and the Polyglutamine expanded protein aggregates in Huntingtons disease and related disorders.

Neurodegenerative diseases

Alzheimers disease (AD)

Hypotheses for what causes AD

Genetics of AD

Chromosome 10

Amyloid plaques

Neurofibrillary tangles




Huntingtons disease (HD)

Motor neurone disease (MND)

Classification of Motor Neurone Diseases

Genetics of MND

Pathological features of ALS

Neuroimaging in MND

Animal models of MND

Mechanisms of neurodegeneration in MND


Niemann Pick type C disease

Parkinsons disease (PD)

Pathological features of PD

Neuroimaging in PD

Drugs used in the treatment of PD

Depression in PD

Cognitive Dysfunction in PD

Visual Search Deficits in PD

Progressive Supranuclear Palsy (PSP)

Research into PSP


Research Tools

Bioinformatic Resources for Proteomics


All members of the Institute of Psychiatry are encouraged to add content to pages.

How to create and edit pages.


What's a Wiki?

Medical Research Council (MRC)

King's College London

Institute of Psychiatry

Neuroscience Department

Mouse Biomedical Informatics Research Network (BIRN)


How to create and edit pages

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Neurodegeneration Research Wiki