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Hypotheses for what causes AD

There are numerous hypotheses regarding the pathogenic sequence of events leading to AD. These include hypotheses that are based on the presence of amyloid plaques and neurofibrillary tangles, cytoskeletal defects, increased levels of oxidative stress, disturbances in calcium homeostasis (reviewed by La Ferla 2002 and pathogens such as herpes simplex virus (HSV) (Robinson et al 2004 Each hypothesis proposes that a primary lesion or defect initiates a series or cascade of events that leads to the development of Alzheimer's disease and its clinical manifestations. The current dominant hypothesis is the [Amyloid Cascade Hypothesis] proposed by Hardy and Allsop 1991 and no alternative hypothesis has as much experimental data to support it (Hardy and Selkoe 2002

Amyloid Cascade Hypothesis

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Hypotheses for what causes AD