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Genetics of AD

Individuals with AD can be classified into four groups depending on family history and age; early and late-onset familial Alzheimer’s disease and early and late-onset sporadic Alzheimer’s disease (EOAD and LOAD, respectively). Classification of sporadic AD is somewhat circumstantial as there may be no family history available to make an alternative diagnosis. Equally there may be no data available because family members have not lived to an age where they have been at risk from developing AD. By definition, EOAD is diagnosed in individuals with an age at onset of less than 65 years of age, while LOAD is diagnosed if the disease develops at or after 65 years of age.

AD is not a normal consequence of aging, and conversely not all patients with AD are elderly. Genetic influences have been shown to underlie both the cognitive and non-cognitive symptomatology of AD. Considerable progress has been made over the past fifteen years in identifying the genetic risk factors for both EOAD and LOAD.

Early onset AD

Sporadic late onset AD

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Genetics of AD